Mezzomerico is a comune (municipality) in the Province of Novara in the Italian region Piedmont, located about 90 kilometres (56 mi) northeast of Turin and about 20 kilometres (12 mi) north of Novara.

Mezzomerico borders the following municipalities: Agrate Conturbia, Divignano, Marano Ticino, Oleggio, Suno, and Vaprio d'Agogna.

The name of the town shows its origins as Celtic Mediomatrici settlement; the name was attested as Mediomadrigo in 980.^[3]