Lyozna (Belarusian: Лёзна, romanized: Liozna; Russian: Лиозно, romanized: Liozno; Polish: Łoźna; German: Ljesno; Yiddish: ליאזנע, romanized: Lyozne) is an urban-type settlement in Vitebsk Region, Belarus.^[1] It serves as the administrative center of Lyozna District.^[2][1] It is located 45 kilometres (28 mi) east-southeast of Vitebsk,^[3] close to the border with Russia by the Vitebsk–Smolensk railroad branch and highway, on the Moshna River. As of 2024, it has a population of 6,605.^[1]

The first known record of the Lyozna shtetl (small town with a high Jewish population) is dated 1654.

In 1939, 711 Jews lived in the settlement, making up 17.3 percent of the population.^[3]

During the German invasion of the Soviet Union, the settlement was captured on 16 July 1941 by V Army Corps of the 9th Army; it was part of Army Group Centre Rear Area.^[3] The ghetto in Lyozna was liquidated at the end of February 1942.^[4] Lyozna remained under German military occupation until 8 October 1943.^[5]

• Marc Chagall, Belarusian-French painter
• Schneur Zalman, the first Rebbe of the Chabad-Lubavitch Hasidic dynasty
• Dovber Schneuri, the second Rebbe of the Chabad-Lubavitch Hasidic dynasty
• Menachem Mendel Schneersohn, the third Rebbe of the Chabad-Lubavitch Hasidic dynasty

• Megargee, Geoffrey P.; Dean, Martin (4 May 2012). The United States Holocaust Memorial Museum Encyclopedia of Camps and Ghettos, 1933 –1945: Volume II: Ghettos in German-Occupied Eastern Europe. Indiana University Press. ISBN 978-0-253-00202-0.

• Lyozna home page
• Lyozna book memory
• Lyozna newspaper "Styag Peramogi"
• Lyozna satellite image
• The murder of the Jews of Lyozna during World War II, at Yad Vashem website
• Lyëzna, Belarus at JewishGen