Khalis (Arabic: خالص) is a given name and surname. Notable people with the name include:
- Khalis Bayyan or Ronald Bell (1951–2020), American singer-songwriter
- Mehdi Khalis (born 1989), Moroccan footballer
- Mohammad Yunus Khalis (c. 1919–2006), Afghan mujahideen commander
- Khalis (comics), fictional character from DC Comics