Sympathomimetic amine
Pharmaceutical compound
Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins).[1][2] Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.
Chemistry
Isometheptene is a monounsaturated aliphatic secondary amine.
Mechanism of action
Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.[3]
See also
- 1,3-Dimethylbutylamine
- 1,4-Dimethylamylamine
- Heptaminol
- Iproheptine
- Methylhexanamine
- Octodrine
- Oenethyl
- Tuaminoheptane
References
- ^ Diamond S, Medina JL (October 1975). "Isometheptene--a non-ergot drug in the treatment of migraine". Headache. 15 (3): 211–3. doi:10.1111/j.1526-4610.1975.hed1503211.x. PMID 1100566. S2CID 34768775.
- ^ Behan PO (December 1978). "Isometheptene compound in the treatment of vascular headache". The Practitioner. 221 (1326): 937–9. PMID 372936.
- ^ "Isometheptene". Drug Bank.
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