Pharmaceutical compound
Fourphit , also known as 4-isothiocyanato-PCP , is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist .[ 1] [ 2] methylphenidate to the DAT in vitro [ 1] in vivo [ 2] stimulant -like effects of cocaine in animals,[ 2] [ 2] acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).[ 1]
See also
References
^ a b c Schweri MM, Thurkauf A, Mattson MV, Rice KC (June 1992). "Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter". J Pharmacol Exp Ther . 261 (3): 936– 942. PMID 1602399 . ^ a b c d Schweri MM, de Costa BR, Rice KC (July 1998). "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats". Pharmacol Biochem Behav . 60 (3): 615– 623. doi :10.1016/s0091-3057(98)00040-9 . PMID 9678644 .
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