Protein-coding gene in humans
Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene .[ 5] [ 6] Purkinje cell survival through downregulation of c-Myc , indicating that CDR2 is a protooncogene .[ 7]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000140743 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030878 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fathallah-Shaykh H, Wolf S, Wong E, Posner JB, Furneaux HM (May 1991). "Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration" . Proc Natl Acad Sci U S A . 88 (8): 3451– 4. Bibcode :1991PNAS...88.3451F . doi :10.1073/pnas.88.8.3451 PMC 51465 PMID 2014264 . ^ "Entrez Gene: CDR2 cerebellar degeneration-related protein 2, 62kDa" .^ Okano, H. J.; Park, W.-Y.; Corradi, J. P.; Darnell, R. B. (1999-08-15). "The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival" . Genes & Development . 13 (16): 2087– 2097. doi :10.1101/gad.13.16.2087 . ISSN 0890-9369 . PMC 316965 PMID 10465786 .
Further reading
Gress T, Baldini A, Rocchi M, et al. (1992). "In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1". Genomics . 13 (4): 1340– 2. doi :10.1016/0888-7543(92)90063-X . PMID 1505970 . Sakai K, Mitchell DJ, Tsukamoto T, Steinman L (1992). "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration" . Ann. Neurol . 30 (5): 738. doi :10.1002/ana.410300523 PMID 1763903 . Sakai K, Mitchell DJ, Tsukamoto T, Steinman L (1991). "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration". Ann. Neurol . 28 (5): 692– 8. doi :10.1002/ana.410280515 . PMID 2260856 . S2CID 28532317 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791– 806. doi :10.1101/gr.6.9.791 PMID 8889548 . Fletcher CF, Okano HJ, Gilbert DJ, et al. (1998). "Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens". Genomics . 45 (2): 313– 9. doi :10.1006/geno.1997.4925 . PMID 9344654 . Takanaga H, Mukai H, Shibata H, et al. (1998). "PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor". Exp. Cell Res . 241 (2): 363– 72. doi :10.1006/excr.1998.4060 . PMID 9637778 . Okano HJ, Park WY, Corradi JP, Darnell RB (1999). "The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival" . Genes Dev . 13 (16): 2087– 97. doi :10.1101/gad.13.16.2087 . PMC 316965 PMID 10465786 . Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X.". Mol. Cell. Neurosci . 19 (4): 477– 84. doi :10.1006/mcne.2001.1059 . PMID 11988016 . S2CID 26659745 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Sutton IJ, Steele J, Savage CO, et al. (2004). "An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies". J. Neuroimmunol . 150 (1– 2): 98– 106. doi :10.1016/j.jneuroim.2003.12.026 . PMID 15081253 . S2CID 45697226 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Balbo M, Barel M, Lottin-Divoux S, et al. (2005). "Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)" . FEMS Microbiol. Lett . 249 (2): 359– 66. doi :10.1016/j.femsle.2005.06.052 PMID 16054780 .
External links
