Sapienza (Italian for 'Knowledge' or 'Wisdom') is the name of a university in Rome, Italy.

Sapienza may also refer to:

• Orto Botanico dell'Università di Roma "La Sapienza", a botanical garden operated by the Sapienza University of Rome, Italy
• San Pellegrino alla Sapienza, a Roman Catholic church in Siena, Italy
• Santa Maria della Sapienza, a Roman Catholic church in Naples, Italy
• Sant'Ivo alla Sapienza, a Roman Catholic church located within the premises of the Sapienza University of Rome, Italy

• Oratorio dell'Eterna Sapienza, a Renaissance confraternity in Milan, Italy
• University of Rome Unitelma Sapienza, a private university in Rome, Italy

• Sapientza or Sapienza, a Greek island located off the southern coast of the Peloponnese
  • Battle of Sapienza, a 1354 battle during the Third Venetian–Genoese War
  • Treaty of Sapienza, a 1209 treaty between the Republic of Venice and the Principality of Achaea

• Al Sapienza, American actor
• Antonio Sapienza (1794–1855), Italian composer and conductor
• Dave Sapienza (born 1965), American stock car racing driver
• Goliarda Sapienza (1924–1996), Italian actress and writer
• Paola Sapienza, Italian-American economist
• Peggy Rae Sapienza (1944–2015), American science fiction fan and con-runner
• Rick Sapienza (born 1936), American football player
• Vincent Sapienza, American civil servant
• Vitor Sapienza (1933–2020), Brazilian politician and economist

• La Sapienza (film), a 2015 dramatic film directed by Eugène Green
• Romano & Sapienza, the previous name of Italian musical group Tacabro
• Sapienza (Hitman), a fictional town and level from the Hitman video game series

• Sapienz
• Sapientia (disambiguation)