Jefferson may refer to:

• Jefferson (surname)
• Jefferson (given name)
• Thomas Jefferson (1743–1826), third president of the United States
• Jefferson (footballer), numerous footballers
• Jefferson, stage name of Geoff Turton (born 1944), British singer

• Jefferson, Alabama
• Jefferson, Columbia County, Arkansas
• Jefferson, Jefferson County, Arkansas
• Jefferson, Colorado
• Jefferson, Camden County, Georgia
• Jefferson, Georgia, the county seat of Jackson County
• Jefferson, Indiana
• Jefferson, Iowa
• Jefferson, Kansas
• Jeffersontown, Kentucky, originally known as Jefferson
• Jefferson, Louisiana
• Jefferson, Maine
• Jefferson, Maryland
• Jefferson, Massachusetts, a village in the town of Holden
• Jefferson, Minnesota
• Jefferson, New Hampshire
• Jefferson, New York, a town
  • Jefferson (CDP), New York, main hamlet in the town
• Jefferson, North Carolina
• Jefferson, Ohio
• Jefferson, Oklahoma
• Jefferson, Oregon
• Jefferson, Greene County, Pennsylvania
• Jefferson, York County, Pennsylvania
• Jefferson Hills, Pennsylvania, a borough formerly known as Jefferson
• Jefferson, South Carolina
• Jefferson, South Dakota
• Jefferson, Texas
• Jefferson, West Virginia
• Jefferson, Wisconsin, a city in Jefferson County
• Jefferson, Green County, Wisconsin, a town
• Jefferson, Jefferson County, Wisconsin, a town
• Jefferson, Monroe County, Wisconsin, a town
• Jefferson, Vernon County, Wisconsin, a town
• Jefferson Prairie Settlement, a former Norwegian settlement in Rock County, Wisconsin
• Jefferson County (disambiguation)
• Jefferson Township (disambiguation)
• List of peaks named Mount Jefferson, a list of mountains named Jefferson
• Jefferson River, Montana, a tributary of the Missouri River
• Jefferson Barracks Military Post, originally named Jefferson Barracks, a former United States Army post near Lemay, Missouri
• Jefferson Territory, an unrecognized territory that existed from 1859 to 1861
• Jefferson (proposed Pacific state), proposed in 1941
• Jefferson (proposed Southern state), proposed in 1915

• Jefferson, Alberta, an unincorporated community

• The Jeffersons, a 1975–1985 American sitcom
• "The Jeffersons" (South Park), a 2004 episode of South Park
• Jefferson, Mississippi, a fictional town where many of William Faulkner's stories are set
• "Jefferson", a song from the album Room Service by Roxette

• Jefferson College (disambiguation)
• Jefferson Community College (disambiguation)
• Jefferson Community and Technical College, a community college in Louisville, Kentucky
• Jefferson Community College (New York), Watertown, New York
• Jefferson, brand name of Thomas Jefferson University, Philadelphia, Pennsylvania
• Jefferson High School (disambiguation)
• Jefferson Middle School (disambiguation)

• Jefferson station (Jacksonville), Florida, a monorail station
• Jefferson Station (SEPTA), Philadelphia, Pennsylvania, a railway station
• Jefferson Lines, a bus company serving the Midwest and West

• Jefferson (elm cultivar), a type of tree
• Rochester Jeffersons, a former National Football League team
• Jefferson Hotel (Richmond, Virginia)
• Jefferson Ward or Jeffersons, a discount department store chain operated by Montgomery Ward until 1988

• Jefferson City (disambiguation)
• Jefferson Literary and Debating Society, a student society at the University of Virginia in the United States
• Jefferson Memorial, Washington, D.C.
• Jefferson method, or D'Hondt method, which are methods of producing proportional representation
• Jefferson Park (disambiguation)
• Jefferson Pools, near Warm Springs, Virginia
• Jefferson State (disambiguation)
• Jefferson Junction, Wisconsin, an unincorporated community
• Jeffersonville (disambiguation)
• Thomas Jefferson (disambiguation)
• Thomas Jefferson National Accelerator Facility, commonly called Jefferson Lab (JLAB)
• The Jefferson Series, a lecture series in New Albany, Ohio