Stictic acid is an aromatic organic compound, a product of secondary metabolism in some species of lichens.[1]

Stictic acid is the subject of preliminary biomedical research. Stictic acid has cytotoxic and apoptotic effects in vitro.[2] Computational studies suggest stictic acid may also stimulate p53 reactivation.[3]

References

  1. ^ Lohézic-Le Dévéhat, Françoise; Tomasi, Sophie; Elix, John A.; Bernard, Aurélie; Rouaud, Isabelle; Uriac, Philippe; Boustie, Joël (2007). "Stictic Acid Derivatives from the Lichen Usnea articulata and Their Antioxidant Activities". Journal of Natural Products. 70 (7): 1218–20. doi:10.1021/np070145k. PMID 17629329.
  2. ^ Correché, ER; Enriz, RD; Piovano, M; Garbarino, J; Gómez-Lechón, MJ (2004). "Cytotoxic and apoptotic effects on hepatocytes of secondary metabolites obtained from lichens". Alternatives to Laboratory Animals. 32 (6): 605–15. doi:10.1177/026119290403200611. PMID 15757498. S2CID 31487885.
  3. ^ Wassman, Christopher D.; Baronio, Roberta; Demir, Özlem; Wallentine, Brad D.; Chen, Chiung-Kuang; Hall, Linda V.; Salehi, Faezeh; Lin, Da-Wei; Chung, Benjamin P.; Wesley Hatfield, G.; Richard Chamberlin, A.; Luecke, Hartmut; Lathrop, Richard H.; Kaiser, Peter; Amaro, Rommie E. (2013). "Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53". Nature Communications. 4: 1407. Bibcode:2013NatCo...4.1407W. doi:10.1038/ncomms2361. PMC 3562459. PMID 23360998.


Allikas: https://en.wikipedia.org/wiki/Stictic_acid
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