Speedball may refer to:

• Speedball (paintball), a paintball game variant
• Speedball (video game), a 1988 video game by Bitmap Brothers

• "Speedball", a song by Black Label Society from 1919 Eternal
• "Speedball", jazz composition by Lee Morgan, originally appearing on The Gigolo and later on Live at the Lighthouse
• "Speedball", a song by John Zorn from Naked City

• Speedball (American ball game), a combination of handball and soccer
• Speed-ball, an Egyptian racquet sport
• Speedball (boxing), a small punching bag used by boxers for training

• Speedball (drug), a mix of heroin and cocaine, or similar drugs
• Speedball (art products), an American art products manufacturer
• Robbie Baldwin, a Marvel Comics superhero known as "Speedball", formerly known as Penance
• "Speedball", a name for the mixed drink Vodka Red Bull
• "Speedball" Mike Bailey, a professional wrestler