Oxygenation may refer to:

• Oxygenation (environmental), a measurement of dissolved oxygen concentration in soil or water
• Oxygen saturation (medicine), The percent of hemoglobin saturated by oxygen, usually in arterial blood.
• Water oxygenation, the process of increasing the oxygen saturation of the water
• Great Oxygenation Event, an ancient event that led to the rise of oxygen within our atmosphere

• Oxygenase, an enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O₂ (as in air) to it
• Oxidation