Locke may refer to:

• John Locke, English philosopher
• Locke (given name)
• Locke (surname), information about the surname and list of people

• Locke, California, a town
• Locke, Indiana, an unincorporated community
• Locke, New York, a town
• Locke Island, in the Columbia River in Washington
• Locke Township, Michigan, a township
• Mount Locke, the site of the McDonald Observatory in the Davis Mountains of West Texas

• Locke (film), a 2013 British film
• Locke the Superman, a 1980s manga series by Yuki Hijiri and its anime film adaptations

• A family in the comic book series Locke & Key and its television series adaptation
• Jameson Locke, the protagonist of the video game Halo 5: Guardians
• John Locke (Lost), a character in the television series Lost
• Locke, a protagonist of the manga Locke the Superman
• Locke Cole, a character from the Final Fantasy VI video game
• Locke, the father of Knuckles the Echidna
• Locke Lamora, the protagonist of the novel The Lies of Locke Lamora
• Locke, pseudonym of Peter Wiggin in Ender’s Game by Orson Scott Card

• Locke High School, Los Angeles, California