People associated with San Sebastian College – Recoletos de Manila.

• Alice Dixson – actress
• Bebe Gandanghari – actor/actress
• Kyla (Melanie Calumpad) – singer (high school)
• Jay Manalo – actor
• Fernando Poe Jr. – actor (1st year-2nd year high school)
• Mat Ranillo III – actor (high school)
• Gladys Reyes – actress
• McCoy de Leon – cast member of the hit Philippine daytime series Be Careful With My Heart; #Hashtag male dancer on the noontime variety show It's Showtime. (high school)

• Calvin Abueva – PBA Alaska Aces player; led NCAA season 88 in points, rebounds, and assist in his final year, NCAA season 87 MVP, NCAA season 85 Men's Basketball Champion
• Rommel Adducul – 5-time NCAA champion, 3-time NCAA MVP
• Ian Sangalang – PBA player, NCAA season 85 Men's Basketball Champion
• Ronald Pascual – PBA player, NCAA season 85 Men's Basketball Champion
• John Raymundo – PBA player, NCAA season 85 Men's Basketball Champion
• Jimbo Aquino – PBA player, NCAA season 85 Men's Basketball Champion
• Gilbert Bulawan – PBA player, NCAA season 85 Men's Basketball Champion
• Marco Alcaraz – actor, model, basketball player
• Paul Alvarez – NCAA, PBA player and actor (college)
• Jason Ballesteros – basketball player, former Smart Gilas Pilipinas player
• Christian Coronel – former PBA player, ABL team Philippine Patriots
• Paul Lee – (high school) PBA player, PBA Rookie of the year, NCAA juniors champion
• Leo Najorda – PBA player
• Fernando Navarro – basketball player and coach
• John Raymundo – PBA player
• Topex Robinson – basketball player, former PBA player, Head Coach of San Sebastian Stags
• Rodney Santos – former PBA player
• Johnedel Cardel – NCAA, and former PBA player
• Homer Se – former PBA player
• JC Tiuseco – actor, model, basketball player; first Pinoy Sole Survivor
• Zanjoe Marudo – actor, model, basketball player;

• Sara Duterte – politician, 15th Vice President of the Philippines, 38th Secretary of Education,Former Mayor of Davao City (LLB)

• Roilo Golez – politician
• Mayor Edward Hagedorn – politician
• Luis Chavit Singson – politician (high school)
• Mans Carpio – Second Gentleman of the Philippines (LLB)
• Antonino Calixto- Member of the Philippine House of Representatives from Pasay, Former Mayor of Pasay City