Kilbirnie is a town in Ayrshire, Scotland. Kilbirnie may also refer to:

• Kilbirnie, Queensland, a locality in the Toowoomba Region, Australia

• Kilbirnie, New Zealand, a suburb of Wellington

• Kilbirnie Loch, a freshwater lake
• Kilbirnie railway station, a former railway station
• Kilbirnie South railway station, a former railway station
• Barony and Castle of Kilbirnie, remains of an old castle