Joseph or Joe Holmes may refer to:

• Joseph Holmes (New Jersey politician) (1736–1809), American politician
• Joseph Erskine Holmes (born 1940), Northern Irish politician
• Joseph John Holmes (1866–1942), Australian politician
• Joseph Warren Holmes (1824–1912), American sea captain
• Joseph William Holmes (1842–?), Canadian politician
• Joe Holmes (born 1963), American heavy metal guitarist
• Joe Holmes (singer) (1906–1978), Irish fiddler, lilter and singer
• Joseph Holmes (photographer), American photographer
• Joseph Austin Holmes (1859–1915), American geologist and occupational safety and health pioneer
• Joseph R. Holmes (1838–1869), African-American politician