Hellfire may refer to:

• Fires of Hell
• The lake of fire

• "Hell-Fire" (story), a 1956 science fiction short story by American writer Isaac Asimov
• Hellfire (book), a 2005 history book written by Cameron Forbes
• Hellfire (comics), various characters
• Hellfire, a power of the Ghost Rider comic book character
• "Hellfire" (Nick Tosches book), a 1982 biography of Jerry Lee Lewis by Nick Tosches

• Hellfire (1949 film), a 1949 western
• Hellfire (1995 film), a TV movie produced by Roger Corman
• Hellfire: A Journey from Hiroshima, a 1986 documentary film
• Hell Fire (2012 film), a 2012 horror film
• "HellFire", an episode from the first season of MacGyver

• Diablo: Hellfire, a 1997 expansion pack to the computer game Diablo from Sierra On-Line
• Hellfire (video game), a 1989 arcade game, later ported to the Mega Drive and PC Engine CD-ROM

• AGM-114 Hellfire, an air-to-surface and surface-to-surface missile system
• Hell-Fire trigger, a device designed to increase the rate of fire of a semi-auto firearm

• Davey "Hellfire" Kelly, one-time guitarist of the Sonic Boom Six
• Hellfire (1349 album), a 2005 album by Norwegian black metal group 1349
• Hellfire (Black Midi album), a 2022 album by English rock band Black Midi

• "Hellfire" (song), a song from the 1996 animated film The Hunchback of Notre Dame
• "Hellfire" (Mango Groove song), a 1989 single by Mango Groove
• "Hellfire", a song from the Soulcalibur II Original Soundtrack (2003)
• "Hellfire", a song from Airbourne's 2008 album Runnin' Wild
• "Hellfire", a song from Gamma ray's 2005 album Majestic
• "Hellfire", a 2017 song by Barns Courtney

• Hellfire preaching
• Hellfire Club (disambiguation)
• Hellfire Pass (disambiguation)
• Lake of Fire (disambiguation)