Grand Canal can refer to multiple waterways:

• Grand Canal (China) in eastern China
• Grand Canal (Ireland), between the River Shannon and Dublin in Ireland
• Grand Canal (Venice) in Venice, Italy
• Grand Canal d'Alsace in eastern France
• Grand Canal (Phoenix) in Arizona, United States
• Grand Canal (Mario), a fictional location appearing in Mario Party 7
• GRAND Canal or Great Recycling and Northern Development Canal, proposed for Great Lakes region of North America
• The proposed Pan Korea Grand Waterway (한반도 대운하) in South Korea, sometimes referred to as the "Grand Canal"
• The proposed Nicaragua Grand Canal that would link the Caribbean Sea and the Pacific Ocean
• The Great Man-Made River in Libya

• The Grand Canal (Streeton) – a 1908 painting by Arthur Streeton