Francesco Simonetta (died 1612) was a Roman Catholic prelate who served as Bishop of Foligno (1606–1612) and Apostolic Nuncio to Poland (1606–1612).

Francesco Simonetta was born in Milan, Italy.^[1] On 17 July 1606, he was appointed during the papacy of Pope Paul V as Bishop of Foligno.^[1] On 23 July 1606, he was consecrated bishop by Girolamo Bernerio, Cardinal-Bishop of Albano, with Galeazzo Sanvitale, Archbishop Emeritus of Bari-Canosa, and Alessandro Guidiccioni (iuniore), Bishop of Lucca, serving as co-consecrators.^[1] On 16 September 1606, he was appointed Apostolic Nuncio to Poland.^[1] He served as Bishop of Foligno until his death in 1612.^[1]

• Cheney, David M. "Nunciature to Poland". Catholic-Hierarchy.org. Retrieved June 16, 2018. (for Chronology of Bishops) ^{[self-published]}
• Chow, Gabriel. "Apostolic Nunciature Poland". GCatholic.org. Retrieved June 16, 2018. (for Chronology of Bishops) ^{[self-published]}
• Cheney, David M. "Diocese of Foligno". Catholic-Hierarchy.org. Retrieved June 16, 2018. (for Chronology of Bishops) ^{[self-published]}
• Chow, Gabriel. "Diocese of Foligno (Italy)". GCatholic.org. Retrieved June 16, 2018. (for Chronology of Bishops) ^{[self-published]}