Custodian may refer to:

• Fullback (rugby league), in rugby, also called a sweeper
• Janitor, a person who cleans and maintains buildings
• Legal guardian or conservator, who may be called a custodian in some jurisdictions

• Custodian of the Holy Land (i.e., Custos), an appointed ecclesiastical office in the Franciscan Order
• Custodian of the Two Holy Mosques, the official title of the head of Saudi Arabia, where the two holiest mosques of Islam are located
• Hashemite custodianship of Jerusalem holy sites, a role claimed by Jordan in administering Jerusalem's holy sites

• Clean-up crew or custodian, a term used for a various arthropods in a terrarium
• The Custodian, a 1993 Australian film
• Custodian bank, an organization responsible for safeguarding a firm's or individual's financial assets
• Custodian helmet, the helmet worn by many members of the British Police Force
• Traditional custodian, a term describing Indigenous Australians' relationship to land

• Custody (disambiguation)