Central Plain or Central Plains may refer to:

• Zhongyuan, a plain in Northern China in the lower reaches of the Yellow River which was the cradle of Chinese civilisation
  • Central Plains Economic Zone
• Central Plain (Wisconsin), one of the geographical regions of Wisconsin
• Central Plains Region, an informal geographic region of the Canadian province of Manitoba
• Central Plains Water, an enhancement scheme for the "Central Plains" of Canterbury, New Zealand
• The South Central Plains taking up most of Piney Woods, a forest terrestrial ecoregion in the Southern United States.
• Central Thailand, a plain in Thailand
• Great Plains, in North America, a portion of which is known as Central Plain
• Central Plains USD 112, a unified school district including various communities in central Kansas, USA