Billy Thompson may refer to:

• Billy Thompson (baseball) (1874–1960), American baseball player
• Billy Thompson (basketball) (born 1963), American basketball player
• Billy Thompson (boxer) (1923–2009), British and European champion lightweight boxer
• Billy Thompson (footballer, born 1886) (1886–1933), English footballer
• Billy Thompson (gunman) (1845–1897), Old West gunman and gambler
• Billy Thompson (ice hockey) (born 1982), Canadian hockey player
• Billy Thompson (soccer, born 1968), American soccer player
• Billy Thompson (soccer, born 1990), American soccer player
• Billy Thompson (American football) (born 1946), American football player
• Billy Thompson (referee) (1933–2021), English rugby league referee

• Billy Thompson, in the UK cartoon strip Billy the Fish

• Billy Thomson (disambiguation)
• Bill Thompson (disambiguation)
• William Thompson (disambiguation)