Big Creek may refer to:

• Big Creek, Tasmania, a tributary of the Inglis River in Tasmania, Australia

• Big Creek, Belize, a sea port in Belize

• Big Creek (British Columbia), a tributary of the Chilcotin River
• Big Creek Provincial Park, a British Columbia Provincial Park
• Big Creek, British Columbia, a locality and former post office in the Chilcotin District of British Columbia
• Big Creek (Lake Erie), empties into Lake Erie at Port Rowan

Alphabetical by state

• Big Creek Lake, formed by damming the Big Creek in southwest Alabama
• Big Creek, California, an unincorporated town in Fresno County
• Big Creek (San Joaquin River), a tributary of the San Joaquin River in California
• Big Creek CCD, Georgia, an unincorporated community in Forsyth County, Georgia
• Big Creek (Georgia), a tributary of the Chattahoochee River
• Big Creek, Idaho, an unincorporated community in Shoshone County
• Big Creek (Des Moines River), a main tributary of the Des Moines River in Iowa
• Big Creek (Kansas), a tributary of the Smoky Hill River
• Big Creek (Perry, Kentucky), a tributary of the North Fork of the Kentucky River
• Big Creek, Kentucky, a tributary of the Red Bird River fork of the South Fork of the Kentucky River
• Big Creek (Kentucky), a tributary of the Tug Fork of the Big Sandy River
• Big Creek (Union Parish, LA), a creek near Marion, Louisiana
• Big Creek (Marshyhope Creek tributary), a stream in Dorchester County, Maryland
• Big Creek, Mississippi, a village in Calhoun County
• Big Creek, Missouri, an unincorporated community
• Big Creek (Castor River tributary), a stream in Missouri
• Big Creek (Cuivre River tributary), a stream in Missouri
• Big Creek (Current River tributary), a stream in Texas and western Shannon counties of Missouri
• Big Creek (Current River East), a stream in Dent, Reynolds and northeast Shannon counties of Missouri
• Big Creek (South Grand River tributary), a stream in Missouri
• Big Creek (Salt River tributary), a stream in Missouri
• Big Creek (St. Francis River), a stream in Missouri
• Big Creek (Northwest Missouri), a stream in Missouri
• Big Creek (Oriskany Creek tributary), a stream in Oneida County, New York
• Big Creek (Cuyahoga River), a tributary of the Cuyahoga River in Northeast Ohio
• Big Creek (Geauga County, Ohio), a stream in Northeast Ohio
• Big Creek (Lane County, Oregon), a stream flowing directly into the Pacific Ocean
• Big Creek Bridge (Oregon)
• Big Creek (Beech River tributary), a stream in Tennessee
• Big Creek (Trinity River), a tributary of the Trinity River (Texas)
• Big Creek High School, in War, West Virginia
• Big Creek (Wisconsin), a stream in Sauk County
• Landels-Hill Big Creek Reserve, a natural reserve in Big Sur, California

• Big Creek Township (disambiguation)