A74 or A-74 may refer to:
- A74 road, a major road in the United Kingdom
- A74(M) and M74 motorways, another road in the United Kingdom that largely replaced the original A74
- Benoni Defense, in the Encyclopaedia of Chess Openings
- HLA-A74, an HLA-A serotype
- Iceberg A-74, an iceberg calved from the Antarctic Brunt Ice Shelf in February 2021
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