5-Methoxy-α,N,N-trimethyltryptamine (5-MeO-α,N,N-TMT), also known as α,N,N,O-tetramethylserotonin (α,N,N,O-TMS), is a little-known synthetic substituted tryptamine and the combined derivative of 5-MeO-DMT and α-methyltryptamine (αMT or AMT).[1][2][3] It is also the N,N-dimethylated derivative of 5-methoxy-α-methyltryptamine (5-MeO-αMT or α,O-DMS) and the N-methylated derivative of 5-methoxy-α,N-dimethyltryptamine (5-MeO-α,N-DMT or α,N,O-TMS).[1][2][3] The compound was described by Alexander Shulgin in TiHKAL as a putative psychedelic drug, but does not appear to have ever been synthesized or assayed.[1][2][3]

See also

References

  1. ^ a b c Shulgin A (1997). Tihkal: The Continuation. Transform Press. #55. α,N,O-TMS. ISBN 978-0-9630096-9-2. Retrieved 17 August 2024. With this, now, as a challenge, predict for me the potency of α,N,N,O-tetramethylserotonin. Here is a compound that has not been yet synthesized, but which carries the second N-methyl group (yet closer to DMT at the nitrogen atom and probably more potent) and yet a structural kiss of death (as to potency) in the MDA/MDMA world. Will it be up? Will it be down? I am afraid that the "make 'em and taste 'em" procedure is the only one that I can trust.
  2. ^ a b c "N,N-Dimethyl-5-methoxy-alpha-methyltryptamine". PubChem. Retrieved 10 January 2025.
  3. ^ a b c "5-MeO-α-methyl-DMT". Isomer Design. 11 November 2024. Retrieved 26 November 2024.



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