FCGR3B (англ. Low affinity immunoglobulin gamma Fc region receptor III-B; CD16B) — мембранный белок, клеточный рецептор, продукт гена человека FCGR3B[1].
Функции
Рецептор для Fc-домена иммуноглобулинов G (IgG). Связывает комплексованными и аггрегированные, а также мономерный IgG. В отличие от FCGR3A FCGR3B не способен опосредовать антитело-зависимую клеточную цитотоксичность и фагоцитоз[2].
Структура
FCGR3A состоит из 233 аминокислоты, молекулярная масса белковой части 26 216 Да. Содережит два иммуноглобилин-подобных домена типа C2[2].
Клиническое значение
Мутации и вариации количаства копий гена ассоциированы с развитием гломерулонефрита[3].
См. также
Примечания
- ↑ Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b).
- ↑ 1 2 UniProtKB — O75015 (FCG3B_HUMAN). Дата обращения: 31 января 2022. Архивировано 31 января 2022 года.
- ↑ Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT (Feb 2006). Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 439 (7078): 851–5. Bibcode:2006Natur.439..851A. doi:10.1038/nature04489. PMID 16482158. S2CID 4421459.
Литература
- Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (May 1990). Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
- Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW (Feb 1989). Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 1013–7. Bibcode:1989PNAS...86.1013P. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732.
- Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP (Jul 1989). A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms. Proceedings of the National Academy of Sciences of the United States of America. 86 (13): 5079–83. Bibcode:1989PNAS...86.5079S. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780.
- Ravetch JV, Perussia B (Aug 1989). Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. The Journal of Experimental Medicine. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846.
- Simmons D, Seed B (Jun 1988). The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein. Nature. 333 (6173): 568–70. Bibcode:1988Natur.333..568S. doi:10.1038/333568a0. PMID 2967436. S2CID 4351255.
- Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (Jan 1995). The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. The Journal of Biological Chemistry. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
- Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (Nov 1996). Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene. The Journal of Biological Chemistry. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
- Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S (Feb 1997). Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb. Blood. 89 (3): 1027–34. doi:10.1182/blood.V89.3.1027. PMID 9028335.
- Zocchi MR, Rubartelli A, Morgavi P, Poggi A (Sep 1998). HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels. Journal of Immunology. 161 (6): 2938–43. PMID 9743356.
- Sondermann P, Huber R, Oosthuizen V, Jacob U (Jul 2000). The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex. Nature. 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521. S2CID 4306592.
- Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD (Sep 2000). Crystal structure of the extracellular domain of a human Fc gamma RIII. Immunity. 13 (3): 387–95. doi:10.1016/S1074-7613(00)00038-8. PMID 11021536.
- Watanabe Y, Shimada E, Fujiwara K, Niihara H, Shimano K, Mitsunaga S, Tadokoro K, Juji T (Sep 2000). Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen. Tissue Antigens. 56 (3): 272–5. doi:10.1034/j.1399-0039.2000.560310.x. PMID 11034564.
- Bharadwaj D, Mold C, Markham E, Du Clos TW (Jun 2001). Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. Journal of Immunology. 166 (11): 6735–41. doi:10.4049/jimmunol.166.11.6735. PMID 11359830.
- Davoine F, Lavigne S, Chakir J, Ferland C, Boulay ME, Laviolette M (Mar 2002). Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions. The Journal of Allergy and Clinical Immunology. 109 (3): 463–9. doi:10.1067/mai.2002.121952. PMID 11897993.
- Fossati G, Moots RJ, Bucknall RC, Edwards SW (May 2002). Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes. Arthritis and Rheumatism. 46 (5): 1351–61. doi:10.1002/art.10230. PMID 12115243.
- Cauza K, Grassauer A, Hinterhuber G, Horvat R, Rappersberger K, Wolff K, Foedinger D (Nov 2002). FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma. The Journal of Investigative Dermatology. 119 (5): 1074–9. doi:10.1046/j.1523-1747.2002.19527.x. PMID 12445195.
- Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K (May 2003). Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens. 61 (5): 374–83. doi:10.1034/j.1399-0039.2003.00047.x. PMID 12753656.
- Breij EC, van der Pol WL, van Winsen L, Jansen MD, Dijkstra CD, van de Winkel JG, Uitdehaag BM (Jul 2003). No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS. Journal of Neuroimmunology. 140 (1–2): 210–5. doi:10.1016/S0165-5728(03)00207-8. PMID 12864991. S2CID 53196500.
- Tong Y, Jin J, Yan L, Neppert J, Marget M, Flesch BK (Sep 2003). FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province. Annals of Hematology. 82 (9): 574–8. doi:10.1007/s00277-003-0725-y. PMID 12898191. S2CID 21478742.
- Tanaka S, Edberg JC, Chatham W, Fassina G, Kimberly RP (Dec 2003). Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins. Journal of Immunology. 171 (11): 6090–6. doi:10.4049/jimmunol.171.11.6090. PMID 14634123.
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