USP may refer to:

• Unité Spéciale de la Police, Luxembourg
• United States Penitentiary, a prison
• Utah State Prison, Draper, US

• Ultra-short period planets, orbiting planets with periods shorter than one day.
• Ultraspiracle protein, a part of the ecdysone receptor
• Universal stress protein, a protein superfamily
• USp (2n), a symplectic group in the mathematics of group theory
• USP grade, a level of chemical purity

• United States patent
• Heckler & Koch USP pistol
• Ultrashort pulse laser, a laser that emits ultrashort pulses of light, generally of the order of femtoseconds to hundreds of femtoseconds
• Universal Storage Platform, brand name for a Hitachi Data Systems line of enterprise storage arrays
• Unified shader processors, used in GPUs
• USP (Victoria), a Russian satellite bus

• University of São Paulo, a public university in Brazil
• University of the Sciences in Philadelphia, United States
• University of the South Pacific, a public university with a number of locations in Oceania
• University of Southeastern Philippines, an educational institution in Mindanao, Philippines
• University of Southern Philippines Foundation, an educational institution in Cebu, Philippines
• University Scholars Program, a scholarly community at Duke University; see John Hope Franklin Center for Interdisciplinary and International Studies

• Unified settlement planning
• Unique selling proposition/Unique selling point, in marketing
• United States Pharmacopeia
• Urs Samyuktha Paksha, an Indian political party
• Useful space principle, in the game of bridge
• Uttama Seva Padakkama, a military decoration in Sri Lanka
• Uspantek language (ISO 639 code: usp), a Mayan language

• All pages with titles beginning with USP
• All pages with titles containing USP