Pentafluorophenol is the organofluorine compound (specifically a fluoroalcohol) with the formula C6F5OH. This is the perfluorinated analogue of phenol. It is a white solid that melts just above room temperature, and smells of phenol. With a pKa of 5.5, it is one of the most acidic phenols.

Uses

Pentafluorophenol is used to prepare pentafluorophenyl esters, which are active esters useful in peptide synthesis.[1]

Environmental hazards

Pentafluorophenol is considered hazardous because of oral, dermal and inhalation toxicity and because it causes severe skin burns and eye damage.[2][3]

References

  1. ^ Jones K, DeAmicis C (2009). "Pentafluorophenol". Encyclopedia of Reagents for Organic Synthesis. pp. 1–9. doi:10.1002/047084289X. hdl:10261/236866.
  2. ^ "Pentafluorophenol SAFETY DATA SHEET". Thermo Fisher Scientific. January 18, 2018. Retrieved 26 February 2021.
  3. ^ "Pentafluorophenol". PubChem. National Center for Biotechnology Information. February 20, 2021. Retrieved 26 February 2021.
Allikas: http://en.wikipedia.org/wiki/Pentafluorophenol
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