María José Portillo Ramírez (born 8 May 1999) is a Mexican tennis player.

She has career-high WTA rankings of 377 in singles and 229 in doubles. Portillo Ramírez has won two singles titles and 18 doubles titles at tournaments of the ITF Women's Circuit.

Playing for the Mexico Fed Cup team, she has a win/loss record of 3–1.

Result	W–L	Date	Tournament	Tier	Surface	Opponent	Score
Win	1–0	May 2018	ITF Tacarigua, Trinidad and Tobago	W15	Hard	Andrea Renée Villarreal	6–2, 6–2
Loss	1–1	May 2019	ITF Cancún, Mexico	W15	Hard	Marcela Zacarías	3–6, 1–6
Win	2–1	Nov 2019	ITF Cancún, Mexico	W15	Hard	Tiphanie Fiquet	6–7(4), 7–5, 6–2
Loss	2–2	Jun 2021	ITF Heraklion, Greece	W15	Clay	Jéssica Bouzas Maneiro	3–6, 0–6
Loss	2–3	Oct 2021	ITF Cancún, Mexico	W15	Hard	Darja Semenistaja	3–6, 5–7
Loss	2–4	Oct 2021	ITF Cancún, Mexico	W15	Hard	Darja Semenistaja	7–5, 6–7(5), 0–6
Loss	2–5	Jan 2022	ITF Cancún, Mexico	W15	Hard	Hina Inoue	6–1, 3–6, 6–7(6)

Result	W–L	Date	Tournament	Tier	Surface	Partner	Opponents	Score
Win	1–0	Nov 2017	ITF Cúcuta, Colombia	W15	Clay	Emily Appleton	Sofía Munera Sánchez Noelia Zeballos	6–3, 7–6(2)
Win	2–0	Nov 2017	ITF Manta, Ecuador	W15	Hard	Sofia Sewing	Emily Appleton María Herazo González	6–1, 6–3
Win	3–0	Dec 2017	ITF Guayaquil, Ecuador	W15	Clay	Sofia Sewing	Stephanie Nemtsova Dominique Schaefer	7–5, 6–2
Loss	3–1	Apr 2018	ITF Pelham, United States	W25	Clay	Maria Mateas	Alexa Guarachi Erin Routliffe	1–6, 2–6
Win	4–1	May 2018	ITF Tacarigua, Trinidad and Tobago	W15	Hard	Emily Appleton	Kerrie Cartwright Kariann Pierre-Louis	6–4, 6–3
Loss	4–2	Nov 2018	ITF Norman, United States	W25	Hard	Sofia Sewing	Vladica Babić Ena Shibahara	2–6, 3–6
Win	5–2	Mar 2019	ITF Cancún, Mexico	W15	Hard	Emily Appleton	Dasha Ivanova Alexandra Perper	7–6(4), 6–4
Loss	5–3	Apr 2019	ITF Cancún, Mexico	W15	Hard	Emily Appleton	Natsumi Kawaguchi Maya Tahan	1–6, 2–6
Win	6–3	May 2019	ITF Cancún, Mexico	W15	Hard	Marcela Zacarías	Eduarda Piai Kirsten-Andrea Weedon	6–2, 6–2
Win	7–3	May 2019	ITF Cancún, Mexico	W15	Hard	Marcela Zacarías	Thaisa Grana Pedretti Eduarda Piai	6–3, 7–6(10)
Win	8–3	Jul 2019	ITF Cancún, Mexico	W15	Hard	Thaisa Grana Pedretti	Dewi Dijkman Isabelle Haverlag	7–5, 6–3
Win	9–3	Jul 2019	ITF Cancún, Mexico	W15	Hard	Thaisa Grana Pedretti	Haine Ogata Aiko Yoshitomi	6–4, 6–4
Win	10–3	Sep 2019	ITF Lubbock, United States	W15	Hard	Sofia Sewing	Shiori Fukuda Ashlyn Krueger	6–2, 6–4
Win	11–3	Nov 2019	ITF Naples, United States	W25	Hard	Gabriela Talabă	Lea Bošković Seone Mendez	7–5, 6–2
Win	12–3	Mar 2021	ITF Amiens, France	W15+H	Clay (i)	Seone Mendez	Elsa Jacquemot Victoria Jiménez Kasintseva	6–4, 6–3
Loss	12–4	Apr 2021	ITF Antalya, Turkey	W15	Clay	María Paulina Pérez	Jang Su-jeong Lee So-ra	2–6, 6–2, [7–10]
Loss	12–5	Jul 2021	ITF The Hague, Netherlands	W25	Clay	Panna Udvardy	Marie Benoît Ioana Loredana Roșca	7–6(5), 5–7, [7–10]
Win	13–5	Sep 2021	ITF Cancún, Mexico	W15	Hard	Victoria Rodríguez	Chelsea Fontenel Qavia Lopez	6–1, 6–1
Loss	13–6	Nov 2021	ITF Orlando, United States	W25	Clay	Marine Partaud	Anna Rogers Christina Rosca	3–6, 1–6
Win	14–6	Nov 2023	ITF Heraklion, Greece	W25	Clay	Martina Colmegna	Margarita Ignatjeva Elena Korokozidi	6–2, 6–4
Loss	14–7	Feb 2024	ITF Mexico City, Mexico	W50	Hard	Thaisa Grana Pedretti	Jessie Aney Jessica Failla	6–3, 4–6, [8–10]
Win	15–7	Apr 2024	ITF Mosquera, Colombia	W35	Clay	Jazmín Ortenzi	Nicole Fossa Huergo Miriana Tona	6–3, 6–2
Win	16–7	May 2024	ITF Anapoima, Colombia	W35	Clay	Jazmín Ortenzi	Nicole Fossa Huergo Miriana Tona	6–4, 6–3
Win	17–7	May 2024	ITF Sopo, Colombia	W35	Clay	Noelia Zeballos	Yuliana Lizarazo Rebeca Pereira	6–4, 6–4
Win	18–7	Sep 2024	ITF Reus, Spain	W35	Clay	Ylena In-Albon	Julia Grabher Caroline Werner	6–4, 6–3

• María Portillo Ramírez at the Women's Tennis Association
• María Portillo Ramírez at the International Tennis Federation
• María Portillo Ramírez at the Billie Jean King Cup (archived)