Isobel is the Scottish form of the female given name Isabel. It originates from the medieval form of the name Elisabeth (Hebrew Elisheba).

People named Isobel include:

• Isobel of Huntingdon (1199-1251), Scottish royalty
• Isobel Baillie (1895-1983), Scottish operatic soprano
• Isobel Barnett (1918-1980), British radio and television personality
• Isobel Buchanan (born 1954), Scottish operatic soprano
• Isobel Campbell (born 1976), Scottish singer, formerly with Belle and Sebastian
• Isobel Lilian Gloag (1865–1917), English painter
• Isobel Gowdie, Scottish woman who was tried for witchcraft in 1662
• Isobel Elsom (1893-1981), English actress
• Isobel Joyce (born 1983), Irish cricketer
• Isobel Loutit (1909–2009), Canadian statistician
• Isobel Miller Kuhn (1901-1957), Canadian missionary
• Isobel Lennart (1915-1971), American screenwriter and playwright
• Isobel Redmond (born 1953), Australian politician
• Isobel Waller-Bridge (born 1984), British composer
• Isobel Yeung (born 1986), British journalist
• Isobel "Izzie" Stevens, a fictional character from the American medical drama Grey's Anatomy
• Isobel Crawley, a fictional character from the British period drama Downton Abbey
• Isobel Flemming, a fictional character from the American The Vampire Diaries
• Isobel (HBC vessel), operated by the HBC from 1850 to 1857, see Hudson's Bay Company vessels