Gertrudis is a feminine given name. People with that name include:

• Gertrudis Anglesola (1641–1727), Valencian abbess and mystic
• Gertrudis Bocanegra (1765–1817), who fought in the Mexican War of Independence
• Gertrudis de la Fuente (1921–2017), Spanish biochemist
• Gertrudis Echenique (1849–1928), First Lady of Chile between 1896 and 1901
• Gertrudis Gómez de Avellaneda (1814–1873), 19th century Cuban born writer who lived in Spain
• Maria Gertrudis "Tules" Barceló (1800–1852), saloon owner and gambler in New Mexico
• Santa Gertrudis (disambiguation)