The 2021 ITS Cup was a professional women's tennis tournament played on outdoor clay courts. It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Olomouc, Czech Republic between 19 and 25 July 2021.^[1]

Country	Player	Rank1	Seed
HUN	Panna Udvardy	204	1
GBR	Francesca Jones	206	2
FRA	Amandine Hesse	211	3
SUI	Susan Bandecchi	219	4
SUI	Simona Waltert	235	5
ITA	Jessica Pieri	244	6
NED	Richèl Hogenkamp	246	7
MEX	Ana Sofía Sánchez	251	8

• ¹ Rankings are as of 12 July 2021.

The following players received wildcards into the singles main draw:

• Nikola Bartůňková
• Sára Bejlek
• Nikola Břečková
• Anna Sisková

The following player received entry using a protected ranking:

• Anna Zaja

The following player received entry using a junior exempt:

• Diane Parry

The following players received entry from the qualifying draw:

• Miriam Bulgaru
• Bárbara Gatica
• Elizabeth Halbauer
• Monika Kilnarová
• Lena Papadakis
• Nika Radišić
• Sapfo Sakellaridi
• Julie Štruplová

• Sára Bejlek def. Paula Ormaechea, 6–0, 6–0

• Jessie Aney / Anna Sisková def. Bárbara Gatica / Rebeca Pereira, 6–1, 6–0

• 2021 ITS Cup at ITFtennis.com
• Official website