A space marine is a science fiction concept, an analogue for military marines in outer space.

Space Marine or Space Marines may also refer to:

• Space Marine (Warhammer 40,000), a type of soldier in the Warhammer 40,000 universe
  • Warhammer 40,000: Space Marine, a 2011 video game based on the property
  • Warhammer 40,000: Space Marine II a 2024 video game based on the property
  • Space Marine, one of several early versions of the miniatures game now known as Epic
• Space Marines (wargame), a miniatures wargame
• Space Marines (film), a 1996 film