Serapion /səˈreɪpiən/ is a given name, a variant of Seraphin.

People called Serapion:

• Serapion of Alexandria (3rd century BC), Greek physician
• Serapion (strategos), probably negotiated in 48 BC for Caesar with Achillas, strategos of Cyprus in 43 BC, executed in 41 BC
• Mara bar Serapion (1st century AD), Syrian stoic
• Serpion of Macedonia (d. 195), martyr
• Serapion of Antioch (c. 200 AD), Patriarch of Antioch
• Serapion (3rd century AD), neoplatonic philosopher, one of the disciples of Plotinus
• Serapion (4th century AD), author of the Sacramentary of Serapion of Thmuis
• Serapion the Sindonite (4th century AD), Egyptian monk and saint
• Yahya ibn Sarafyun (9th century), also known as Serapion the Elder or Johannes Serapion, Christian physician who wrote two medical compilations in Syriac
• Serapion of Algiers (1179–1240), Mercedarian saint
• Serapion the Younger (c. 12th century), physician who wrote The Book of Simple Medicine (in Arabic)
• Serapion of Vladimir (13th century), bishop of Vladimir
• Serapion of Novgorod (d. 1516), Russian archbishop
• Serapion (Coptic bishop of Los Angeles) (b. 1951)
• Serapion Kolosnitsin (1964–2025), Russian Orthodox archbishop of Kokshetau and Akmola

• Sarapion (Serapion), ancient port city in present-day south-central Somalia
• Saint Serapion (Zurbarán), an oil on canvas painting by the Spanish artist Francisco de Zurbarán
• Serapion Brothers, a literary movement in the early Soviet Union