Four-time defending champion Esther Vergeer and her partner Sharon Walraven defeated Daniela Di Toro and Aniek van Koot in the final, 6–3, 6–3 to win the women's doubles wheelchair tennis title at the 2010 US Open.

Korie Homan and Vergeer were the reigning champions, but Homan did not participate.

1. Daniela Di Toro / Aniek van Koot (final)
2. Esther Vergeer / Sharon Walraven (champions)

	Semifinals							Finals
	1	Daniela Di Toro Aniek van Koot	6	6
		Annick Sevenans Mackenzie Soldan	2	3
								1	Daniela Di Toro Aniek van Koot	3	3
								2	Esther Vergeer Sharon Walraven	6	6
		Florence Alix-Gravellier Jiske Griffioen	4	4
	2	Esther Vergeer Sharon Walraven	6	6

• Main Draw