River Esk is the name of:

• River Esk, North Yorkshire, in the North York Moors National Park and the county of North Yorkshire
• River Esk (Ravenglass), in the Lake District National Park and the county of Cumbria
• River Esk (Solway Firth), in the north of the county of Cumbria and along the border with Scotland, also known as the Border Esk

• River Esk (Solway Firth), in Dumfries and Galloway and along the border with England, also known as the Border Esk
• River Esk, Lothian, which runs for much of its length as two separate tributaries, the North Esk and the South Esk
• River North Esk, in Angus and Aberdeenshire
• River South Esk, in Angus

• Esk River (New South Wales), a tributary of the Clarence River
• Esk River (Queensland)
• North Esk River a river in Tasmania, Australia
• South Esk River a river in Tasmania, Australia

• Esk River (Canterbury), New Zealand
• Esk River (Hawke's Bay), New Zealand

• North Esk (disambiguation)
• South Esk (disambiguation)