The 45th Annual Tony Awards was broadcast by CBS from the Minskoff Theatre on June 2, 1991. The hosts were Julie Andrews and Jeremy Irons.

Shows that opened on Broadway during the 1990–1991 season before May 2, 1991 are eligible.

Presenters: Carol Channing, Joan Collins, Tyne Daly, Whoopi Goldberg, Joel Grey, Steve Guttenberg, Audrey Hepburn, Raul Julia, Jackie Mason, Shirley MacLaine, James Naughton, Penn & Teller, Anthony Quinn, Lily Tomlin, Denzel Washington

Musicals represented:

• Miss Saigon ("The Heat is On in Saigon"/"Last Night of the World"/"I Still Believe"/"You Will Not Touch Him"/"The American Dream" - Lea Salonga, Jonathan Pryce. Company)
• Once on This Island ("The Human Heart"/"Mama Will Provide" - La Chanze, Lillias White, Company)
• The Secret Garden (Medley - Company)
• The Will Rogers Follies ("Will-A-Mania"/"Favorite Son" - Keith Carradine, Cady Huffman, Company)

Special Salute:

• How to Succeed in Business Without Really Trying ("The Year of the Musical Actor"/"I Believe in You" - Robert Morse)
• Fiddler on the Roof ("If I Were a Rich Man" - Topol)
• Bye Bye Birdie ("Rosie" - Tommy Tune and Ann Reinking [a live remote from Seattle])
• My Fair Lady and Camelot medley performed by Julie Andrews ("Wouldn't It Be Loverly" "Camelot" "I Could Have Danced All Night")
• The Phantom of the Opera ("Music of the Night" - Michael Crawford)

Winners are in bold

• Regional Theatre Award -- Yale Repertory Theater, New Haven, Connecticut
• Tony Honor—Father George Moore (Given Posthumously)

• Drama Desk Awards
• 1991 Laurence Olivier Awards – equivalent awards for West End theatre productions
• Obie Award
• New York Drama Critics' Circle
• Theatre World Award
• Lucille Lortel Awards

• Official Site Tony Awards