The 2021 Open International de Tennis de Roanne was a professional tennis tournament played on indoor hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Roanne, France between 8 and 14 November 2021.

Country	Player	Rank1	Seed
FRA	Benoît Paire	47	1
FRA	Richard Gasquet	74	2
CZE	Jiří Veselý	86	3
SWE	Mikael Ymer	97	4
SUI	Henri Laaksonen	98	5
AUT	Dennis Novak	107	6
MDA	Radu Albot	127	7
FRA	Antoine Hoang	168	8
FRA	Hugo Grenier	183	9

• ¹ Rankings are as of 1 November 2021.^[1]

The following players received wildcards into the singles main draw:

• Arthur Cazaux
• Giovanni Mpetshi Perricard
• Benoît Paire

The following player received entry into the singles main draw using a protected ranking:

• Julien Cagnina

The following player received entry into the singles main draw as an alternate:

• Kyrian Jacquet

The following players received entry from the qualifying draw:

• Gabriel Debru
• Calvin Hemery
• Georgii Kravchenko
• Alexey Vatutin

The following players received entry as lucky losers:

• Vladyslav Orlov
• Jelle Sels
• Luca Vanni

• Hugo Grenier def. Hiroki Moriya 6–2, 6–3.

• Lloyd Glasspool / Harri Heliövaara def. Romain Arneodo / Albano Olivetti 7–6^(7–5), 6–7^(5–7), [12–10].