Up most often refers to the relative direction opposed to down. It may also refer to:

• Up! (1976 film), a sex comedy by Russ Meyer
• Up (1984 film), an Oscar-winning short film by Mike Hoover and Tim Huntley
• Up (2009 film), an animated feature by Disney/Pixar

• The Up, a Detroit protopunk band

• Up (ABC album), 1989
• Up (Right Said Fred album), 1992
• Up (Great Big Sea album), 1995
• Up (R.E.M. album), 1998
• Up (Peter Gabriel album), 2002
• Up! (album), by Shania Twain, 2002
• Up (soundtrack), for the Disney/Pixar film, 2009
• Up (Pop Evil album), 2015

• "Up" (Aespa song), 2024
• "Up" (Cardi B song), 2021
• "Up" (Inna song), 2021
• "Up" (James Morrison song), 2011
• "Up" (Olly Murs song), 2014
• "Up" (The Saturdays song), 2008
• "Up!" (Bini & BGYO song), 2022
• "Up!" (LoveRance song), 2011
• "Up!" (Samantha Jade song), 2014
• "Up!" (Shania Twain song), 2002
• "Up", a 2021 song by Dune Rats
• "Up", a song by Justin Bieber from the 2010 album My World 2.0
• "Up!", a song by M83 from the 2008 album Saturdays = Youth
• "Up", a song by Nav from the 2017 mixtape Nav
• "Up", a song by Oneohtrix Point Never from the 2011 album Replica
• "Up", a 2007 song by Rob Crow
• "Up", a song by Take That from the 2017 album Wonderland

• Up (TV channel), formerly known as GMC
• Up (TV program), on MSNBC
• Up (film series), a British documentary series following several people over their lives

• Up (video game), based on the Disney/Pixar film
• Up!, a musical comedy also known as Via Galactica

• Up (airline), a former low-cost airline
• Bahamasair, IATA airline code UP
• Union Pacific Railroad
• Union Pearson Express, or UP Express, an airport rail link in Toronto, Canada
• United Press International, a news agency
• Abbreviation for university press
• Up (Australian bank), a digital bank

• -up, a suffix in Australian place names
• United Provinces (disambiguation)
• University Park, Pennsylvania, United States
• University Park, Texas, United States
• Upper Peninsula of Michigan, United States
• Uttar Pradesh, India
• Eup (administrative division), also spelled ŭp, an administrative unit in both North Korea and South Korea

• National Popular Party (Romania), a Romanian political party, "Uniunea Patrioților" in Romanian
• Patriotic Union (Colombia), a Colombian political party
• Labour United, a Polish political party, "Unia Pracy" in Polish
• Unidad Popular, a Chilean coalition of political parties
• Unidade Popular, a Brazilian political party
• Union for the Homeland, an Argentine political coalition, "Unión por la Patria" in Spanish
• United Party (disambiguation), any of several political parties
• Unity Party (disambiguation), any of several political parties

• Palacký University Olomouc, Czech Republic
• Panamerican University, Mexico, "Universidad Panamericana" in Spanish
• Pedagogical University, Mozambique
• Umutara Polytechnic, Rwanda
• University of Patras, Greece
• University of Pennsylvania, United States
• University of the Philippines, national university system of the Philippines
• University of Phoenix, United States
• University of Poitiers, France
• University of Portland, United States
• University of Porto, Portugal
• University of Potsdam, Germany
• University of Pretoria, South Africa

• Uncertainty principle, a fundamental limit to measurement precision
• Unified Process, a software development process framework
• Unrotated projectile, an anti-aircraft weapon
• UP (complexity)
• Up (game theory)
• Up quark, in physics
• Upper Paleolithic, a stone age

• Volkswagen Up, an automobile
• Up, a cocktail term
• Up, a railroad direction
• Up, a term in sports designating one's turn, similar to "at bat" in baseball
• Underpowered (game balance)
• Unitary patent, also known as "European patent with unitary effect", a type of European patent

• All pages with titles beginning with up
• All pages with titles containing Up
• Up Up Up Up Up Up, a 1999 album by Ani DiFranco
• Upp (disambiguation)
• Upward (disambiguation)
• Position (geometry)
• Straight up (bartending)
• ↑ (disambiguation) (up arrow)
• 1-up, an extra life in video games
• N-up, a printing page layout