Resistance Is Futile may refer to:
- Resistance Is Futile (Oh Hiroshima), a 2012 studio album by Oh Hiroshima
- Resistance Is Futile (album), a 2018 studio album by the Manic Street Preachers
- Resistance Is Futile!, a 2018 book by Ann Coulter
- "Resistance is futile", a phrase spoken in the 1977 episode "The Dorcons" of the TV show Space: 1999
- "Resistance Is Futile" (Dexter), a 2007 broadcast episode of Dexter
- "Resistance is futile", a phrase uttered by the Borg in Star Trek
- The phrase "resistance is futile" appeared in a 1976 "Doctor Who" episode called "The Deadly Assassin".
- "Resistance would be futile", a phrase spoken in episode of "Lost in Space (1965)" titled "Wreck of the Robot" that aired on Dec 14, 1966.