Call of Cthulhu may refer to:

• "The Call of Cthulhu", the original 1928 short story by H. P. Lovecraft

• The Call of Cthulhu (film), a 2005 silent film, distributed by the H. P. Lovecraft Historical Society
• Call Girl of Cthulhu, an indie horror film by Chris LaMartina

• Call of Cthulhu (role-playing game), published by Chaosium (first edition, 1981)
• Call of Cthulhu: Shadow of the Comet, a 1993 adventure game
• Call of Cthulhu: The Card Game (2008), published by Fantasy Flight Games
• Call of Cthulhu: Dark Corners of the Earth, a 2005 first-person survival horror video game
• Call of Cthulhu: The Wasted Land, a 2012 tactical RPG video game
• Call of Cthulhu (video game), a 2018 survival horror role-playing video game

• "The Call of Ktulu", a track on the 1984 Metallica album Ride the Lightning

• The Call of Cthulhu and Other Weird Stories, an anthology of works by H. P. Lovecraft
• "The Collect Call of Cathulhu", an episode of The Real Ghostbusters (1987)