Althiomycin (matamycin) is a thiazole antibiotic, effective against Gram-positive and Gram-negative bacteria. The name matamycin is from "Mata Hari"[1] and the suffix -mycin.

Isolated from Streptomyces matensis, the compound was first described by Margalith et al. in 1959.[2] It acts a protein synthesis inhibitor and its site of action is the 50S subunit of the bacterial ribosome.[2]

References

  1. ^ Aronson J (October 1999). "That's show business". BMJ (Clinical Research Ed.). 319 (7215): 972. doi:10.1136/bmj.319.7215.972. PMC 1116803. PMID 10514162.
  2. ^ a b Pestka S (1975). "Althiomycin". In Corcoran JW, Hahn FE, Snell JF, Arora KL (eds.). Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics. Berlin Heidelberg: Springer-Verlag. pp. 323–6. doi:10.1007/978-3-642-46304-4_21. ISBN 978-3-642-46304-4.
Allikas: http://en.wikipedia.org/wiki/Althiomycin
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