Рецептор интерлейкина 5, субъединица альфа (англ. Interleukin 5 receptor, alpha, IL5Rα, IL5RA; CD125) — белок, субъединица рецептора интерлейкина 5, продукт гена человека IL5RA[5]
Функции
Белок IL5Rα — субъединица рецептора интерлейкина 5, гетеродимерного цитокинового рецептора. Рецептор состоит из α-субъединицы, специфической для лиганда, и β-субъединицы (CD131), передающей сигнал, причём β-субъединица входит в состав комплексного рецептора не только интерлейкина 3, но и рецепторов таких цитокинов, как ГМ-КСФ и интерлейкин 3. Связывание интерлейкина 5 зависит от бета-субъединицы, которая активируется при связывании с лигандом и определяет биологическую активность цитокина. Кроме этого, IL5Rα связывается с SDCBP, что необходимо для активации фактора транскрипции SOX4, опосредуемой интерлейкином 5[5].
Взаимодействия
IL5Rα взаимодействует со следующими белками:
Структура
Белок состоит из 420 аминокислот, молекулярная масса 47,7 кДа. Альтернативный сплайсинг приводит к образованию 6 изоформ.
Примечания
- ↑ 1 2 3 GRCh38: Ensembl release 89: ENSG00000091181 - Ensembl, May 2017
- ↑ 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005364 - Ensembl, May 2017
- ↑ Ссылка на публикацию человека на PubMed: Национальный центр биотехнологической информации, Национальная медицинская библиотека США.
- ↑ Ссылка на публикацию мыши на PubMed: Национальный центр биотехнологической информации, Национальная медицинская библиотека США.
- ↑ 1 2 Entrez Gene: IL5RA interleukin 5 receptor, alpha.
- ↑ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (Nov 1994). Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.
- ↑ Johanson K, Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid SS, Young P, Cook R, Carr S, Matico R (Apr 1995). Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. J. Biol. Chem. 270 (16): 9459–71. doi:10.1074/jbc.270.16.9459. PMID 7721873.
- ↑ Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K (Feb 1992). Molecular cloning and expression of the human interleukin 5 receptor. J. Exp. Med. 175 (2): 341–51. doi:10.1084/jem.175.2.341. PMC 2119102. PMID 1732409.
- ↑ Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K (Apr 1998). JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. Blood. 91 (7): 2264–71. doi:10.1182/blood.V91.7.2264. PMID 9516124.
- ↑ Cen O, Gorska MM, Stafford SJ, Sur S, Alam R (Mar 2003). Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID 12496276.
- ↑ Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (Aug 2001). Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591. S2CID 28003281.
Литература
- Isobe M, Kumura Y, Murata Y, Takaki S, Tominaga A, Takatsu K, Ogita Z (1992). Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14 (3): 755–8. doi:10.1016/S0888-7543(05)80180-6. PMID 1427903.
- Tuypens T, Plaetinck G, Baker E, Sutherland G, Brusselle G, Fiers W, Devos R, Tavernier J (1993). Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene. Eur. Cytokine Netw. 3 (5): 451–9. PMID 1477296.
- Tavernier J, Tuypens T, Plaetinck G, Verhee A, Fiers W, Devos R (1992). Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. Proc. Natl. Acad. Sci. U.S.A. 89 (15): 7041–5. Bibcode:1992PNAS...89.7041T. doi:10.1073/pnas.89.15.7041. PMC 49641. PMID 1495999.
- Scott HS, Guo XH, Hopwood JJ, Morris CP (1992). Structure and sequence of the human alpha-L-iduronidase gene. Genomics. 13 (4): 1311–3. doi:10.1016/0888-7543(92)90053-U. PMID 1505961.
- Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K (1992). Molecular cloning and expression of the human interleukin 5 receptor. J. Exp. Med. 175 (2): 341–51. doi:10.1084/jem.175.2.341. PMC 2119102. PMID 1732409.
- Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G (1991). A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell. 66 (6): 1175–84. doi:10.1016/0092-8674(91)90040-6. PMID 1833065. S2CID 54277241.
- Johanson K, Appelbaum E, Doyle M, Hensley P, Zhao B, Abdel-Meguid SS, Young P, Cook R, Carr S, Matico R (1995). Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. J. Biol. Chem. 270 (16): 9459–71. doi:10.1074/jbc.270.16.9459. PMID 7721873.
- Sun Z, Yergeau DA, Tuypens T, Tavernier J, Paul CC, Baumann MA, Tenen DG, Ackerman SJ (1995). Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene. J. Biol. Chem. 270 (3): 1462–71. doi:10.1074/jbc.270.3.1462. PMID 7836416.
- Hori K, Hirashima M, Ueno M, Matsuda M, Waga S, Tsurufuji S, Yodoi J (1993). Regulation of eosinophil migration by adult T cell leukemia-derived factor. J. Immunol. 151 (10): 5624–30. PMID 8228251.
- Huston MM, Moore JP, Mettes HJ, Tavana G, Huston DP (1996). Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. J. Immunol. 156 (4): 1392–401. PMID 8568239.
- Monahan J, Siegel N, Keith R, Caparon M, Christine L, Compton R, Cusik S, Hirsch J, Huynh M, Devine C, Polazzi J, Rangwala S, Tsai B, Portanova J (1997). Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. J. Immunol. 159 (8): 4024–34. PMID 9378992.
- Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K (1998). JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. Blood. 91 (7): 2264–71. doi:10.1182/blood.V91.7.2264. PMID 9516124.
- Tavernier J, Van der Heyden J, Verhee A, Brusselle G, Van Ostade X, Vandekerckhove J, North J, Rankin SM, Kay AB, Robinson DS (2000). Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit. Blood. 95 (5): 1600–7. doi:10.1182/blood.V95.5.1600.005k22_1600_1607. PMID 10688814.
- Czabotar PE, Holland J, Sanderson CJ (2000). Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction. Cytokine. 12 (7): 867–73. doi:10.1006/cyto.1999.0663. PMID 10880230.
- Plugariu CG, Wu SJ, Zhang W, Chaiken I (2001). Multisite mutagenesis of interleukin 5 differentiates sites for receptor recognition and receptor activation. Biochemistry. 39 (48): 14939–49. doi:10.1021/bi001467p. PMID 11101310.
- Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (2001). Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591. S2CID 28003281.
- Upham JW, Sehmi R, Hayes LM, Howie K, Lundahl J, Denburg JA (2002). Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells. J. Allergy Clin. Immunol. 109 (2): 307–13. doi:10.1067/mai.2002.121527. PMID 11842302.
- Rizzo CA, Yang R, Greenfeder S, Egan RW, Pauwels RA, Hey JA (2002). The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness. J. Allergy Clin. Immunol. 109 (3): 404–9. doi:10.1067/mai.2002.122459. PMID 11897983.
- Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM (2003). Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes. Anal. Biochem. 307 (2): 258–65. doi:10.1016/S0003-2697(02)00043-X. PMID 12202242.
- Liu LY, Sedgwick JB, Bates ME, Vrtis RF, Gern JE, Kita H, Jarjour NN, Busse WW, Kelly EA (2002). Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. J. Immunol. 169 (11): 6452–8. doi:10.4049/jimmunol.169.11.6452. PMID 12444154.
