Van Dyck or Vandyck is a Dutch toponymic surname meaning "from (the) dike", originally written Van Dijck. Notable people with the surname include:

• Abraham van Dyck (1635–1680), Dutch painter (preferred spelling "van Dijck")
• Albert Van Dyck (1902–1951), Belgian painter
• Anthony van Dyck (1599–1641), Flemish artist, court painter in England
• Christopher H. van Dyck (born 1955), American neuroscientist
• Cornelius Van Alen Van Dyck (1819–1895), American missionary
• Edouard Van Dyck (1918–1977), Belgian professional road bicycle racer
• Elisabeth Van Dyck (1951–1979), German member of the Red Army Faction
• Ernest van Dyck (1861–1923), Belgian dramatic tenor
• Floris van Dyck (1575–1651), Dutch painter
• Henry H. Van Dyck (1809–1888), New York politician
• Jeff van Dyck (born 1969), Australian video game music composer
• Marijuana Pepsi Vandyck, American educator
• Max Van Dyck (1902–1992), Belgian painter
• Steve Van Dyck, Australian zoologist and museum curator
• Vedder Van Dyck (1889–1960), American Episcopal bishop
• William Vandyck, British actor and children's author
• William V. B. Van Dyck (1875–1981), American football player, electrical engineer, and businessman

• Van Dijck
• Van Dijk
• Van Dyk
• Van Dyke (disambiguation)
• Walther von Dyck (1856–1934), German mathematician
• Dick Van Dyke, American actor and comedian
• Anthony Van Dyck (horse) (2016-2020), Irish thoroughbred race horse