Todeschini may refer to:
- Bruno Todeschini (born 1962), Swiss actor
- Federico Todeschini (born 1975), Argentine rugby union footballer
- Federico Todeschini (economist) (born 1978), Argentine economist
- Jean-Marc Todeschini (born 1952), member of the Senate of France
- Paolo Todeschini (1920 – 1993), Italian professional footballer
- Giacomo Francesco Cipper, also known as Il Todeschini - Austrian-Italian still life painter
- Giacomo Todeschini (born 1950), Italian historian
- Pope Pius III (1439 – 1503), born Francesco Todeschini