In molecular biology, Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing.[2][3]
References
- ^ Ganot P, Caizergues-Ferrer M, Kiss T (April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development. 11 (7): 941–56. doi:10.1101/gad.11.7.941. PMID 9106664.
- ^ Kiss T, Bortolin ML, Filipowicz W (April 1996). "Characterization of the intron-encoded U19 RNA, a new mammalian small nucleolar RNA that is not associated with fibrillarin". Molecular and Cellular Biology. 16 (4): 1391–400. doi:10.1128/MCB.16.4.1391. PMC 231123. PMID 8657112.
- ^ Bortolin ML, Kiss T (April 1998). "Human U19 intron-encoded snoRNA is processed from a long primary transcript that possesses little potential for protein coding". RNA. 4 (4): 445–54. PMC 1369630. PMID 9630250.
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