Skyy is a brand of vodka.
Skyy may also refer to:
- Alexis Skyy (born 1994), American television personality
- Skyy Moore (born 2000), American football player
- Skyy (band), a former American band
- Skyy (album), the band's 1979 debut album
- Skyy Radio 106.6FM, a commercial radio station in Sierra Leone