Semiramis InterContinental Hotel is a skyscraper and hotel complex located in Garden City, Cairo, Egypt. The 32-story building completed in 1987, and houses an InterContinental hotel. The modernist building replaced the historic Semiramis hotel, and contains 726 rooms and suites, restaurants, bars, a cafe, outdoor Nile view terraces, a Spa, a gym, ballrooms, conference and meeting rooms, a shopping arcade and a casino.

During the Second World War, the former Semiramis Hotel served as the headquarters of the 2nd Anti-Aircraft Brigade, whose task was to build up the permanent defences at the main port harbours.^[2]

In late 1993, American and French tourists were shot dead at the hotel in a terrorist attack.^[3]

• Skyscraper design and construction
• List of tallest buildings in Africa