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Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.[5][6]

TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important for T cell fate.[7]

Interactions

TRA2B has been shown to interact with RBMX.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136527Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022858Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SFRS10 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)".
  6. ^ Nayler O, Cap C, Stamm S (October 1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.
  7. ^ Karginov, Timofey A.; Ménoret, Antoine; Leclair, Nathan K.; Harrison, Andrew G.; Chandiran, Karthik; Suarez-Ramirez, Jenny E.; Yurieva, Marina; Karlinsey, Keaton; Wang, Penghua; O’Neill, Rachel J.; Murphy, Patrick A.; Adler, Adam J.; Cauley, Linda S.; Anczuków, Olga; Zhou, Beiyan (2024-09-13). "Autoregulated splicing of TRA2 β programs T cell fate in response to antigen-receptor stimulation". Science. 385 (6714). doi:10.1126/science.adj1979. ISSN 0036-8075.
  8. ^ Hofmann, Yvonne; Wirth Brunhilde (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. ISSN 0964-6906. PMID 12165565.

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