Petrucci is an Italian surname. Notable people with the surname include:

15th–19th centuries

• Alessandro Petrucci (died 1628), Italian Roman Catholic Archbishop of Siena and Bishop of Massa Marittima
• Alfonso Petrucci (c. 1490–1517), Italian Roman Catholic cardinal
• Antonello Petrucci, also known as Antonello d'Aversa (died 1487), Italian Baron and secretary to King Ferdinand I of Naples
• Borghese Petrucci (1512–1516), Italian politician, ruler of Siena
• Domenico Petrucci (died 1598), Italian Roman Catholic Bishop of Bisignano and later Bishop of Strongoli
• Giovanni Alfonso Petrucci (1650–1688), Roman Catholic Bishop of Belcastro
• Ottaviano Petrucci (1466–1539) Italian printer, producer of sheet music
• Pandolfo Petrucci (1452–1512) ruler of Siena
• Pier Matteo Petrucci, C.O. (1636–1701), Italian Roman Catholic cardinal
• Raffaello Petrucci (1472–1522), cardinal, ruler of Siena

20th century

• A. J. Petrucci, American professional wrestler
• Cinzia Petrucci (born 1955) Italian shot putter
• Danilo Petrucci (born 1991) Italian motorcyclist
• Davide Petrucci (born 1991) Italian football (soccer) player
• Gianni Petrucci (born 1945) Italian sports director
• Giovanna Petrucci (born 1998), Brazilian athlete
• John Petrucci (born 1967) American rock guitarist
• Loretto Petrucci (1929–2016) Italian cyclist
• Luigi Petrucci (born 1956) Italian actor
• Mario Petrucci (born 1958), English poet, literary translator, educator and broadcaster
• Roxy Petrucci (born 1960) American drummer