Pendergast (Irish: de Piondárgas, Piondárgas) is a Norman-Irish surname derived from Prendergast. Notable people with the surname include:
- Aloysius Pendergast, character in novels by Douglas Preston and Lincoln Child.
- Clancy Pendergast (born 1967), American football coach
- James Pendergast (1856–1911), American politician from Kansas City, Missouri; brother of Tom Pendergast
- Jane Pendergast, American biostatistician
- Leeanna Pendergast (born 1962), Canadian politician from Ontario
- Tom Pendergast (1872–1945), American political boss from Kansas City, Missouri; brother of James Pendergast
- Tom Pendergast (footballer) (1870–1946), English footballer